Publications

Salling MC, Pleil KE.  2024.  A Little "Re-Cognition" Goes a Long Way for Pro-Cognitive Therapeutics in Alcohol Studies. J Pharmacol Exp Ther. 389(3):254-257.

Zallar LJ, Rivera-Irizarry JK, Hamor PU, Pigulevskiy I, Rozo A-SRico, Mehanna H, Liu D, Welday JP, Bender R, Asfouri JJ et al..  2024.  Rapid nongenomic estrogen signaling controls alcohol drinking behavior in mice. Nat Commun. 15(1):10725.

Rivera-Irizarry JK, Zallar LJ, Levine OB, Skelly MJane, Boyce JE, Barney T, Kopyto R, Pleil KE.  2023.  Sex differences in binge alcohol drinking and the behavioral consequences of protracted abstinence in C57BL/6J mice. Biol Sex Differ. 14(1):83.

Hartmann MC, Pleil KE.  2021.  Circuit and neuropeptide mechanisms of the paraventricular thalamus across stages of alcohol and drug use. Neuropharmacology. 198:108748.

Levine OB, Skelly MJane, Miller JD, Rivera-Irizarry JK, Rowson SA, DiBerto JF, Rinker JA, Thiele TE, Kash TL, Pleil KE.  2021.  The paraventricular thalamus provides a polysynaptic brake on limbic CRF neurons to sex-dependently blunt binge alcohol drinking and avoidance behavior in mice. Nat Commun. 12(1):5080.

Acosta-Ruiz A, Gutzeit VA, Skelly MJane, Meadows S, Lee J, Parekh P, Orr AG, Liston C, Pleil KE, Broichhagen J et al..  2020.  Branched Photoswitchable Tethered Ligands Enable Ultra-efficient Optical Control and Detection of G Protein-Coupled Receptors In Vivo. Neuron. 105(3):446-463.e13.

Odell SC, Taki F, Klein SLiba, Chen RJ, Levine OB, Skelly MJane, Nabila A, Brindley E, Toth JGal, Dündar F et al..  2020.  Epigenomically Bistable Regions across Neuron-Specific Genes Govern Neuron Eligibility to a Coding Ensemble in the Hippocampus. Cell Rep. 31(12):107789.

Radke AK, Jury NJ, Kocharian A, Marcinkiewcz CA, Lowery-Gionta EG, Pleil KE, McElligott ZA, McKlveen JM, Kash TL, Holmes A.  2017.  Chronic EtOH effects on putative measures of compulsive behavior in mice. Addict Biol. 22(2):423-434.

Rinker JA, S Marshall A, Mazzone CM, Lowery-Gionta EG, Gulati V, Pleil KE, Kash TL, Navarro M, Thiele TE.  2017.  Extended Amygdala to Ventral Tegmental Area Corticotropin-Releasing Factor Circuit Controls Binge Ethanol Intake. Biol Psychiatry. 81(11):930-940.

Pleil KE, Helms CM, Sobus JR, Daunais JB, Grant KA, Kash TL.  2016.  Effects of chronic alcohol consumption on neuronal function in the non-human primate BNST. Addict Biol. 21(6):1151-1167.

Navarro M, Olney JJ, Burnham NW, Mazzone CM, Lowery-Gionta EG, Pleil KE, Kash TL, Thiele TE.  2016.  Lateral Hypothalamus GABAergic Neurons Modulate Consummatory Behaviors Regardless of the Caloric Content or Biological Relevance of the Consumed Stimuli. Neuropsychopharmacology. 41(6):1505-12.

Li C, Sugam JA, Lowery-Gionta EG, McElligott ZA, McCall NM, Lopez AJ, McKlveen JM, Pleil KE, Kash TL.  2016.  Mu Opioid Receptor Modulation of Dopamine Neurons in the Periaqueductal Gray/Dorsal Raphe: A Role in Regulation of Pain. Neuropsychopharmacology. 41(8):2122-32.

J Hardaway A, Jensen J, Kim M, Mazzone CM, Sugam JA, DiBerto JF, Lowery-Gionta EG, Hwa LS, Pleil KE, Bulik CM et al..  2016.  Nociceptin receptor antagonist SB 612111 decreases high fat diet binge eating. Behav Brain Res. 307:25-34.

Pleil KE, Lowery-Gionta EG, Crowley NA, Li C, Marcinkiewcz CA, Rose JH, McCall NM, Maldonado-Devincci AM, A Morrow L, Jones SR et al..  2015.  Effects of chronic ethanol exposure on neuronal function in the prefrontal cortex and extended amygdala. Neuropharmacology. 99:735-49.

Kash TL, Pleil KE, Marcinkiewcz CA, Lowery-Gionta EG, Crowley N, Mazzone C, Sugam J, J Hardaway A, McElligott ZA.  2015.  Neuropeptide regulation of signaling and behavior in the BNST. Mol Cells. 38(1):1-13.

Vardy E, J Robinson E, Li C, Olsen RHJ, DiBerto JF, Giguere PM, Sassano FM, Huang X-P, Zhu H, Urban DJ et al..  2015.  A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior. Neuron. 86(4):936-946.

Pleil KE, Rinker JA, Lowery-Gionta EG, Mazzone CM, McCall NM, Kendra AM, Olson DP, Lowell BB, Grant KA, Thiele TE et al..  2015.  NPY signaling inhibits extended amygdala CRF neurons to suppress binge alcohol drinking. Nat Neurosci. 18(4):545-52.

Zhu H, Pleil KE, Urban DJ, Moy SS, Kash TL, Roth BL.  2014.  Chemogenetic inactivation of ventral hippocampal glutamatergic neurons disrupts consolidation of contextual fear memory. Neuropsychopharmacology. 39(8):1880-92.

Masneuf S, Lowery-Gionta E, Colacicco G, Pleil KE, Li C, Crowley N, Flynn S, Holmes A, Kash T.  2014.  Glutamatergic mechanisms associated with stress-induced amygdala excitability and anxiety-related behavior. Neuropharmacology. 85:190-7.

Jennings JH, Sparta DR, Stamatakis AM, Ung RL, Pleil KE, Kash TL, Stuber GD.  2013.  Distinct extended amygdala circuits for divergent motivational states. Nature. 496(7444):224-8.

Sparrow AM, Lowery-Gionta EG, Pleil KE, Li C, Sprow GM, Cox BR, Rinker JA, Jijon AM, Peňa J, Navarro M et al..  2012.  Central neuropeptide Y modulates binge-like ethanol drinking in C57BL/6J mice via Y1 and Y2 receptors. Neuropsychopharmacology. 37(6):1409-21.

Holmes A, Fitzgerald PJ, MacPherson KP, DeBrouse L, Colacicco G, Flynn SM, Masneuf S, Pleil KE, Li C, Marcinkiewcz CA et al..  2012.  Chronic alcohol remodels prefrontal neurons and disrupts NMDAR-mediated fear extinction encoding. Nat Neurosci. 15(10):1359-61.

Pleil KE, Lopez A, McCall N, Jijon AM, Bravo JPeña, Kash TL.  2012.  Chronic stress alters neuropeptide Y signaling in the bed nucleus of the stria terminalis in DBA/2J but not C57BL/6J mice. Neuropharmacology. 62(4):1777-86.

Lowery-Gionta EG, Navarro M, Li C, Pleil KE, Rinker JA, Cox BR, Sprow GM, Kash TL, Thiele TE.  2012.  Corticotropin releasing factor signaling in the central amygdala is recruited during binge-like ethanol consumption in C57BL/6J mice. J Neurosci. 32(10):3405-13.

Li C, Pleil KE, Stamatakis AM, Busan S, Vong L, Lowell BB, Stuber GD, Kash TL.  2012.  Presynaptic inhibition of gamma-aminobutyric acid release in the bed nucleus of the stria terminalis by kappa opioid receptor signaling. Biol Psychiatry. 71(8):725-32.