Submitted by cad3002 on February 20, 2025 - 2:42pm
| Title | Chronic alcohol remodels prefrontal neurons and disrupts NMDAR-mediated fear extinction encoding |
| Publication Type | Journal Article |
| Year of Publication | 2012 |
| Authors | Holmes A, Fitzgerald PJ, MacPherson KP, DeBrouse L, Colacicco G, Flynn SM, Masneuf S, Pleil KE, Li C, Marcinkiewcz CA, Kash TL, Gunduz-Cinar O, Camp M |
| Journal | Nat Neurosci |
| Volume | 15 |
| Issue | 10 |
| Pagination | 1359-61 |
| Date Published | 2012 Oct |
| ISSN | 1546-1726 |
| Keywords | Action Potentials, Animals, Dendrites, Down-Regulation, Ethanol, Extinction, Psychological, Fear, Mice, Neurons, Prefrontal Cortex, Receptors, N-Methyl-D-Aspartate |
| Abstract | Alcoholism is frequently co-morbid with post-traumatic stress disorder, but it is unclear how alcohol affects the neural circuits mediating recovery from trauma. We found that chronic intermittent ethanol (CIE) impaired fear extinction and remodeled the dendritic arbor of medial prefrontal cortical (mPFC) neurons in mice. CIE impaired extinction encoding by infralimbic mPFC neurons in vivo and functionally downregulated burst-mediating NMDA GluN1 receptors. These findings suggest that alcohol may increase risk for trauma-related anxiety disorders by disrupting mPFC-mediated extinction of fear. |
| DOI | 10.1038/nn.3204 |
| Alternate Journal | Nat Neurosci |
| PubMed ID | 22941108 |
| PubMed Central ID | PMC3471649 |
| Grant List | U01 AA020911 / AA / NIAAA NIH HHS / United States AA019454 / AA / NIAAA NIH HHS / United States K99 AA017668 / AA / NIAAA NIH HHS / United States R00 AA017668 / AA / NIAAA NIH HHS / United States AA020911 / AA / NIAAA NIH HHS / United States R01 AA019454 / AA / NIAAA NIH HHS / United States F32 AA021043 / AA / NIAAA NIH HHS / United States AA021043 / AA / NIAAA NIH HHS / United States AA017668 / AA / NIAAA NIH HHS / United States ZIA AA000411-08 / / Intramural NIH HHS / United States |